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RET V804M-IN-1
CAS No. 2414909-94-5
RET V804M-IN-1( LUN09945,RETV804M kinase inhibitor )
Catalog No. M22008 CAS No. 2414909-94-5
RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | Get Quote |
|
| 5MG | 65 | Get Quote |
|
| 10MG | 87 | Get Quote |
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| 25MG | 151 | Get Quote |
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| 50MG | 237 | Get Quote |
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| 100MG | 335 | Get Quote |
|
| 200MG | 494 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRET V804M-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionRET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
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DescriptionRET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
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In VitroRET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively.
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In Vivo——
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SynonymsLUN09945,RETV804M kinase inhibitor
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PathwayTyrosine Kinase
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Targetc-RET
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RecptorRETV804M
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Research Area——
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Indication——
Chemical Information
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CAS Number2414909-94-5
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Formula Weight344.37
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Molecular FormulaC19H16N6O?
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Purity>98% (HPLC)
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SolubilityDMSO:120mg/ml (348.46 Mm; Need ultrasonic)
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SMILESNC(=O)C1=CC=C(C=C1)C1=C2N=C(NCC3=CC=CN=C3)C=CN2N=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.
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RET V804M-IN-1
RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
